2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W105700
    Ethylenediaminetetraacetic acid sodium hydrate 10378-23-1 ≥98.0%
    Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid sodium hydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid sodium hydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid sodium hydrate can be used for coronary artery disease and neural system disease research.
    Ethylenediaminetetraacetic acid sodium hydrate
  • HY-W400424
    (-)-6α-Hydroxy cannabidiol 58940-28-6 ≥99.0%
    (-)-6α-Hydroxy cannabidiol is a metabolite of Cannabidiol.
    (-)-6α-Hydroxy cannabidiol
  • HY-W414548
    7α,27-Dihydroxycholesterol 4725-24-0 99.00%
    7α,27-Dihydroxycholesterol is an oxysterol characterized by its oxidized side chains and is produced through the hydroxylation of 27-Hydroxycholesterol (27-OHC); it serves as a metabolite of interest in lipidomic analyses of various pathological conditions, including neurological diseases, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome, and diabetes. Notably, levels of 7α,27-di-OHC decrease following lipopolysaccharide activation, and it also functions as a ligand for Epstein-Barr virus-induced gene 2 (EBI2). Additionally, 7α,27-di-OHC exists as a structural isomer of 7α,25-dihydroxycholesterol (7α25-OHC).
    7α,27-Dihydroxycholesterol
  • HY-W417914
    4-Methylamphetamine hydrochloride 41632-56-8 99.86%
    4-Methylamphetamine hydrochloride is a 5-HT1A receptor agonist that induces hypothermia in rats by binding to the 5-HT1A receptor. Additionally, 4-Methylamphetamine hydrochloride acts on norepinephrine (NE), dopamine (DA), and serotonin (5-HT) transporters to increase the extracellular levels of these neurotransmitters. 4-Methylamphetamine hydrochloride can be used in the study of neurological disorders.
    4-Methylamphetamine hydrochloride
  • HY-W505344
    Bromo-dragonFLY hydrochloride 219986-78-4
    Bromo-dragonFLY hydrochloride is a phenethylamine.
    Bromo-dragonFLY hydrochloride
  • HY-W585874
    Nε-(Carboxyethyl)lysine 5746-03-2 ≥99.0%
    Nε-(Carboxyethyl)lysine is an advanced glycation end product (AGE). Nε-(Carboxyethyl)lysine causes cross-linking between proteins, affects the structure and function of proteins, and leads to protein denaturation. Nε-(Carboxyethyl)lysine binds to RAGE receptors, affects cell signaling, regulates processes such as inflammatory response, cell proliferation and apoptosis. Nε-(Carboxyethyl)lysine affects glutamate transporter, reduces glutamate uptake and S100B protein secretion, affects neurotransmission in the nervous system, and exhibits diabetic-related neurotoxicity.
    Nε-(Carboxyethyl)lysine
  • HY-W588212
    trans-Permethrin 61949-77-7 99.88%
    trans-Permethrin is a transconfiguration of Permethrin (HY-B0887). Permethrin is an insecticide and neurotoxin.
    trans-Permethrin
  • HY-W753791
    (±)-Perillaldehyde 2111-75-3
    (±)-Perillaldehyde has an antidepressant effect by modulating the olfactory nervous system in a mouse model of stress-induced depression. (±)-Perillaldehyde also has anti-inflammatory activity, inducing JNK activation in RAW264.7 cells and inhibiting the expression of TNF-α, with an IC50 of 171.7 μM.
    (±)-Perillaldehyde
  • HY-Y1373S1
    Cyclohexanecarboxylic acid-d11 93131-16-9 99.14%
    Cyclohexanecarboxylic acid-d11 is the deuterium labeled Cyclohexanecarboxylic acid[1]. Cyclohexanecarboxylic acid is a Valproate structural analogue with anticonvulsant action[2].
    Cyclohexanecarboxylic acid-d11
  • HY-100046S1
    Nordoxepin-d4 hydrochloride 2249819-14-3 99.90%
    Nordoxepin-d4 (Desmethyldoxepin-d4) hydrochloride is deuterium-labeled Nordoxepin (hydrochloride) (HY-100046).
    Nordoxepin-d4 hydrochloride
  • HY-113123S1
    LysoPC(14:0/0:0)-d7
    LysoPC(14:0/0:0)-d7 (14:0 Lyso PC-d7) is deuterium labeled LysoPC(14:0/0:0). LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect.
    LysoPC(14:0/0:0)-d7
  • HY-123689S1
    Samidorphan-d5
    Samidorphan-d5 (ALKS-33-d5) is is a deuterated compound of Samidorphan. Samidorphan is an orally active opioid system modulator that binds with high affinity to μ-opioid, κ-opioid, and δ-opioid receptors. Samidorphan is a μ-opioid receptor antagonist and a partial agonist at k-opioid and δ-opioid receptors. Samidorphan acts primarily as an opioid receptor antagonist in vivo.
    Samidorphan-d5
  • HY-B1811AS1
    Vasopressin-d5 TFA
    Vasopressin-d5 TFA is the TFA salt form of Vasopressin-d5 (HY-B1811S1). Vasopressin-d5 TFA is an isotope-labeled compound of Vasopressin (HY-B1811). Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of the corticotropin-releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors.
    Vasopressin-d5 TFA
  • HY-D148410F
    Cy5-Zorevunensen negative control 99.68%
    Cy5-Zorevunensen negative control (Cy5-STK-001 negative control) is an antisense oligonucleotide labeled with the fluorescent molecule Cy5, which can be used as a negative control for Zorevunersen (HY-148410).
    Cy5-Zorevunensen negative control
  • HY-W012998R
    2,3-Pentanedione (Standard) 600-14-6
    2,3-Pentanedione (Standard) is the analytical standard of 2,3-Pentanedione. This product is intended for research and analytical applications. 2,3-Pentanedione is a common constituent of synthetic flavorings and is used to impart a butter, strawberry, caramel, fruit, rum, or cheese flavor in beverages, ice cream, candy, baked goods, gelatins, and puddings. 2,3-Pentanedione also occurs naturally as a fermentation product in beer, wine, and yogurt and is releasedduring roasting of coffee beans.
    2,3-Pentanedione (Standard)
  • HY-W016474A
    1-(4-Fluorophenyl)piperazine hydrochloride 64090-19-3
    1-(4-Fluorophenyl)piperazine (1-(4-Fluorophenyl)piperazinediium) hydrochloride is a substituted phenylpiperazine.
    1-(4-Fluorophenyl)piperazine hydrochloride
  • HY-W1118061
    9-cis-13,14-Dihydroretinoic acid 176019-01-5
    9-cis-13,14-Dihydroretinoic acid (9CDHRA) is a selective retinoid X receptor (RXR) agonist with a Kd value of 90 nM. 9-cis-13,14-Dihydroretinoic acid improves memory deficits caused by impaired RXR signaling in vivo. 9-cis-13,14-Dihydroretinoic acid is promising for research of neuroscience and metabolic disease.
    9-cis-13,14-Dihydroretinoic acid
  • HY-W342604R
    N-Acetylputrescine (Standard) 5699-41-2
    1,4-Dicaffeoylquinic acid (Standard) is the analytical standard of 1,4-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid from Xanthii fructus, inhibits LPS-stimulated TNF-α production.
    N-Acetylputrescine (Standard)
  • HY-W017389S1
    Xanthine-15N2 161770-53-2 99.35%
    Xanthine-15N2 is a 15N-labeled Xanthine (HY-W017389). Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation.
    Xanthine-15N2
  • HY-W017443S2
    L-Asparagine-13C4,15N2,d3 monohydrate 2483829-30-5 99.90%
    L-Asparagine-13C4,15N2,d3 monohydrate is the deuterium, 13C-, and 15N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
    L-Asparagine-13C4,15N2,d3 monohydrate
Cat. No. Product Name / Synonyms Application Reactivity