2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0546AR
    Procaine hydrochloride (Standard) 51-05-8 99.75%
    Procaine (hydrochloride) (Standard) is the analytical standard of Procaine (hydrochloride). This product is intended for research and analytical applications. Procaine hydrochloride is a DNA-demethylating agent. Procaine hydrochloride acts through multiple targets and has a slow onset and a short duration of action.
    Procaine hydrochloride (Standard)
  • HY-B0647S1
    Butylphthalide-d3 99.81%
    Butylphthalide-d3 is the deuterium labeled Butylphthalide. Butylphthalide(3-n-Butylphthalide), an anti-cerebral-ischemia agent, is first isolated from the seeds of celery and showes efficacy in animal models of stroke.
    Butylphthalide-d3
  • HY-B0716S1
    Urapidil-d3 1398066-08-4 99.93%
    Urapidil-d3 is the deuterium labeled Urapidil. Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist.
    Urapidil-d3
  • HY-B0863S2
    Glyphosate-d2-1 99.89%
    Glyphosate-d2-1 is the deuterium labeled Glyphosate. Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants.
    Glyphosate-d2-1
  • HY-B0863S3
    Glyphosate-13C2,15N 1185107-63-4 ≥98.0%
    Glyphosate-13C2,15N is the 13C and 15N labled Glyphosate (HY-B0863). Glyphosate is an herbicidal derivative of the amino acid glycine. Glyphosate targets and blocks a plant metabolic pathway not found in animals, the shikimate pathway, required for the synthesis of aromatic amino acids in plants.
    Glyphosate-13C2,15N
  • HY-B1039AS
    Ambroxol-d5 hydrochloride 2741380-71-0 99.46%
    Ambroxol-d5 (hydrochloride) is the deuterium labeled Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.
    Ambroxol-d5 hydrochloride
  • HY-N0111S2
    Coenzyme Q10-d9 2687960-97-8 98.23%
    Coenzyme Q10-d9 is the deuterium labeled Coenzyme Q10. Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.
    Coenzyme Q10-d9
  • HY-N0304S1
    L-DOPA-13C6 201417-12-1 ≥98.0%
    L-DOPA-13C6 is the 13C-labled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease.
    L-DOPA-13C6
  • HY-N0473S6
    L-Tyrosine-3,5-13C2 70479-98-0 99.43%
    L-Tyrosine-3,5-13C2 is the 13C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
    L-Tyrosine-3,5-13C2
  • HY-N0680S2
    Thiamine-d4 hydrochloride
    Thiamine-d4 (hydrochloride) is deuterium labeled Thiamine (hydrochloride). Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.
    Thiamine-d4 hydrochloride
  • HY-N0682S1
    Pyridoxine-d2 hydrochloride 5027-82-7 98.89%
    Pyridoxine-d2 (hydrochloride) is the deuterium labeled Pyridoxine hydrochloride. Pyridoxine hydrochloride is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
    Pyridoxine-d2 hydrochloride
  • HY-N10546A
    Ganglioside GM1 (bovine) ammonium 1007119-81-4 ≥98.0%
    Ganglioside GM1 (bovine) ammonium is a member of the ganglioside family that can be used for neurological disease research. Ganglioside GM1 (bovine) ammonium is a functional tissue receptor for the Cholera Toxin1.
    Ganglioside GM1 (bovine) ammonium
  • HY-N12486A
    (3S,8R,9R)-Isofalcarintriol 2962060-53-1 98%
    (3S,8R,9R)-Isofalcarintriol is a natural polyacetylene compound found in carrot root parts. (3S,8R,9R)-Isofalcarintriol is a potent longevity promoter that improves glucose metabolism and has anti-tumor activity. (3S,8R,9R)-Isofalcarintriol can affect cellular respiration, interact with the α subunit of mitochondrial ATP synthase, and promote mitochondrial biogenesis. (3S,8R,9R)-Isofalcarintriol can be used in the study of neurodegenerative diseases, metabolic diseases, and aging.
    (3S,8R,9R)-Isofalcarintriol
  • HY-P10737A
    CGGK acetate
    CGGK acetate is a control peptide of CAQK peptide (HY-P10216).
    CGGK acetate
  • HY-P991046
    Donanemab (Mouse IgG2b) 98%
    Donanemab (Mouse IgG2b) is an anti-amyloid inhibitory antibody with Mouse IgG2b. Donanemab can be used in research about Alzheimer's disease.
    Donanemab (Mouse IgG2b)
  • HY-U00050S
    (E)-10-Hydroxynortriptyline-d3 99.65%
    (E)-10-Hydroxynortriptyline-d3 is a deuterium labeled (E)-10-Hydroxy Nortriptyline. (E)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.
    (E)-10-Hydroxynortriptyline-d3
  • HY-U00123A
    Guanoxabenz hydrochloride 23256-40-8 99.72%
    Guanoxabenz (Hydroxyguanabenz) hydrochloride is an α2 adrenergic receptor agonist, with a Ki of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor.
    Guanoxabenz hydrochloride
  • HY-W000665
    2,6-Dimethyl-L-tyrosine 123715-02-6 99.94%
    2,6-Dimethyl-L-tyrosine (Dmt) is a tyrosine derivative that enhances receptor affinity, functional bioactivity and in vivo analgesia of opioid peptides.
    2,6-Dimethyl-L-tyrosine
  • HY-W001692
    Ocinaplon 96604-21-6 99.70%
    Ocinaplon (DOV 273547) is a partial GABAA receptor positive allosteric modulator with relatively high efficacy at the α1 subunit.
    Ocinaplon
  • HY-W004425
    DMPX 14114-46-6 98%
    DMPX (3,7-Dimethyl-1-propargylxanthine) is a BBB-penetrable caffeine analogue. DMPX is A2 selective adenosine receptor (AR) antagonist that strongly and selectively blocks hypothermia and behavioral inhibition induced by A2 adenosine receptor agonists such as NECA (HY-103173). DMPX can be used in the study of Parkinson's disease and other diseases.
    DMPX
Cat. No. Product Name / Synonyms Application Reactivity